Does Monocyte To High Density Lipoprotein Cholesterol Ratio Predict Saphenous Vein Graft Patency In Patients With Stable Angina Pectoris?

Introduction: Circulating monocyte count is a predictive factor for new atherosclerotic plaque development. Also, there is a strong inverse relationship between high density lipoprotein cholesterol (HDL) and atherosclerosis. It has been shown that monocyte count/HDL ratio (MHR) is a novel inflammatory marker. We aimed to investigate the relationship between MHR and saphenous vein graft disease (SVGD). Materials and Methods: A total of 369 patients were divided into three groups (with positive SVGD group = 150, negative SVGD group = 89, normal coronary artery group = 130). Baseline characteristics and laboratory parameters were recorded and compared between groups. Results: There were no statistically differences between SVGD positive and negative groups except age of SVG and left ventricular ejection fraction according to baseline characteristics. C-reactive protein, fasting blood glucose and mean platelet volume were higher in patients with positive SVGD group than negative SVGD group (respectively p values = 0.008, 0.048 and 0.042). MHR value was not statistically different between SVGD positive and negative groups ( p = 0.169) and normal coronary artery group ( p= 0.364). CRP was found an independent predictor factor of SVGD. Conclusion: There was no association between MHR and coronary atherosclerosis. MHR was not a predictive factor for SVGD.